Abstract
Momordica dioica (M. dioica) is a gourd like blooming plant that is readily available in Bangladesh, requiring biological research to discover its therapeutic values. The goal of our research was to see if the ethanolic extract of this plant had any anti-hyperglycemic properties. Water, glibenclamide and M. dioica extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25 g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen and lipid contents. Except for the control group, all the groups followed a pattern of maintaining the body weight. The oral glucose tolerance test was observed to be improved in extract after 14 days of the experiment. When assessed with the control group, the M. dioica extract showed a significant (p = 0.0015) decrease in postprandial serum glucose level (M±SD, mmol/l, 13.23 ± 1.03 control Vs 11.47 ± 2.21 extract) at 120 min. The treatment of diabetic model rats with extract resulted in a 7% (p < 0.0001) reduction in serum cholesterol levels. While subsequent 28 days of treatment, insulin levels were found to be lowered in all groups (from 246.76 to 200.44 pg/dL; p < 0.0001 for standard and from 309.01 to 204.61 pg/dL; p < 0.0001 for sample). The results revealed that prolonged administration of M. dioica improved the glycemic and lipidemic state of type-2 diabetic rats, implying that more research is needed to identify the active ingredient (s).
Highlights
Diabetics are a category of metabolic disorders in which the body no longer generates insulin or produces it in insufficient amounts, resulting in abnormally high blood sugar levels
Serum insulin was measured by using the enzyme-linked immunosorbent assay (ELISA) method according to the manufacturer's instructions (Crystal Chem Inc., Downers Grove, IL, USA)
The results of the phytochemical analysis of dried fruits of M. dioica indicated the presence of saponin, flavonoid, phenol, alkaloid, carbohydrates and terpenoid like phytoconstituents (Table 1)
Summary
Diabetics are a category of metabolic disorders in which the body no longer generates insulin or produces it in insufficient amounts, resulting in abnormally high blood sugar levels. Diabetics cause several complications, including metabolic disorders of carbohydrate, lipid, and protein in the body, as well as vasculopathies [1, 2]. According to a recent epidemiological study in Bangladesh, the prevalence of diabetes mellitus is higher among the elderly [5]. The average annual cost of diabetes care in Bangladesh is US$864.7 per patient, which is significantly higher than many other countries [7]. Aside from side effects, treatments with drugs are not always satisfactory to avoiding late-stage diabetic complications and maintaining euglycemia. Health care professionals are increasingly looking for medicinal herbs with antihyperglycemic properties as an alternative treatment option for diabetic patients [8]. Many traditional plant treatments are a hidden treasure trove of effective natural diabetic products
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
