Abstract
Antibiotics play a vital role in combating diseases caused by pathogenic bacteria. Consumption of antibiotics may emit certain undesirable side effects. Hence, there is an initiative to discover new novel natural products with therapeutic potential, which is safer and can combat various ailments. Peperomia pellucida, which belongs to Piperaceae family, is a herbal plant that can be found in many regions of tropical Asia. This study aimed to extract P. pellucida and screen its phytochemical compositions, and finally test its antibacterial activity on gram positive and gram-negative bacteria. Ethanolic extraction was conducted to obtain a crude extract of the leaf sample. Phytochemical test screenings were also carried out. Antibacterial assay by agar well diffusion was done for the antibacterial activity to determine the minimum inhibitory concentration (MIC). The results showed that the ethanolic leave extract of P. pellucida contains steroids and tannins. The extract exhibited the maximum inhibition zones of 15.67 ± 0.58 mm, 9.67 ± 1.58 mm and 10.67 ± 0.58 mm against E. coli, P. aeruginosa and S. aureus respectively. Based on the MIC test, the ethanolic leaf extracts have shown potential antibacterial activity.
Highlights
The emergence of novel diseases caused by pathogenic bacteria has increased over the years (Vouge and Greub, 2016)
This study aimed to determine the phytochemical compositions of P. pellucida ethanolic extract and to determine its antibacterial activity on selected gram-positive and gram-negative bacteria
Peperomia pellucida was collected from the Glasshouse and Nursery Complex (GNC), International Islamic University Malaysia (IIUM) Kuantan, Pahang
Summary
The emergence of novel diseases caused by pathogenic bacteria has increased over the years (Vouge and Greub, 2016). These harmful bacteria may produce toxins that can deteriorate human health. For this reason, antibiotics play a vital role in combating diseases. Scientists continuously seek alternatives, especially from medicinal plant products, which could enhance the effectiveness of present antibiotics. Peperomia pellucida or locally known as “sireh cina,” is believed to exhibit antimicrobial properties (Fernandez et al, 2012; Mutee et al, 2010; De Fatima et al, 2004). It is very crucial to conduct extensive research on medicinal plants to evaluate the promising biological properties that are valuable in the pharmaceutical industry. This study aimed to determine the phytochemical compositions of P. pellucida ethanolic extract and to determine its antibacterial activity on selected gram-positive and gram-negative bacteria
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
