Abstract
Objectives: Leonotis Nepetifolia (Family: Lamiaceae) is a herb distributed in central and eastern peninsular India which is used as bitter tonic in fevers and also used in pneumonia, flu, mouth and lip infections. The present study focuses on the investigation of antiemetic activity of Leonotis Nepetifolia leaf extract. Method: The study includes preliminary investigation of phytochemical constituents followed by the antiemetic activity of Leonotis Nepetifolia leaf extract on 2-4 days male chicks (32-52gms). Results: The results reveal the presence of bioactive constituents comprising alkaloids, flavonoids, phenolics, tannins, glycosides, steroids and saponins in different solvents and also have antiemetic potential comparable with that of the reference drug Metoclopramide. Ethanol extract of 200 mg/kg inhibited the retches up to 73.761%, which inhibited emesis to an extent equal to Metoclopramide at 50mg/kg. Conclusion: The antiemetic potential of Leonotis Nepetifolia leaf extract may be due to the presence of phytoconstituents like alkaloids and terpenoids.
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