Phytochemical Screening and Anti-dandruff Activity of Fruit Husk Extracts of Cassia fistula Lin

Abstract

Medicinal plants play a substantial role in treating various disorders. This study aims to evaluate the phytochemicals and anti-dandruff activity of a fruit husk of Cassia fistula Linn as a remedy for treating dandruff. Various extracts of fruit husk were extracted using sequential extraction methods, namely n-hexane, chloroform, and methanol. Primarily, the polyphenols and flavonoids of the various extracts were determined. The methanol extract contained the maximum number of polyphenols (48.97 ± 0.27), while the flavonoids were found in a large amount in the n-hexane extract (123.0 ± 0.82). Anti-dandruff activity was performed using a well-diffusion method against Malassezia species. At 1.0 g/mL concentration, n-hexane showed a zone of inhibition of 12.5 mm, while 18.50 mm and 20.50 mm at concentrations of 1.5 g/mL and 2.0 g/mL, respectively. At the concentration of 3000 mg/mL, the inhibition zone of 23.60 mm was observed. Extracts of Cassia fistula linn were effective for the treatment of dandruff. Therefore, in vivo studies are crucially required to explore the mechanism of action.