Abstract
Mangroves represent areas of high biological productivity and it is a region rich in bioactive substances used in medicine production. Conocarpus erectus (Combretaceae) known as button mangrove is one of the species found in mangroves and it is used in folk medicine in the treatment of anemia, catarrh, conjunctivitis, diabetes, diarrhea, fever, gonorrhea, headache, hemorrhage, orchitis, rash, bumps and syphilis. The present study aimed to investigate the acute toxicity of aqueous extract of leaves of C. erectus in Swiss albino mice. The plant material was collected in Vila Velha mangroves, located in Itamaracá (PE). The material was subjected to a phytochemical screening where extractive protocols to identify majority molecules present in leaves were used. The evaluation of acute toxicity of aqueous extract of C. erectus followed the model of Acute Toxicity Class based on OECD 423 Guideline, 2001. The majority molecules were identified: flavonoids, tannins and saponins. The LD50 was estimated at 2,000 mg/kg bw. Therefore, the aqueous extract showed low acute toxicity classified in category 5.
Highlights
Conocarpus erectus L., popularly known as mangrove button belongs to the family Combretaceae and it is found in tropical and subtropical regions around the world (Bandeira 2003)
The determination of acute toxicity is the first step in toxicological investigations of aqueous extract of Conocarpus erectus L., consti tuting a preliminary pharmacognostic, exploring resources manipulated by the population
The aqueous extract of C. erectus L. showed the presence of flavonoids, tannins and saponins and absence of alkaloids, coumarins, and triterpenes (Figure 1)
Summary
Conocarpus erectus L., popularly known as mangrove button belongs to the family Combretaceae and it is found in tropical and subtropical regions around the world (Bandeira 2003). The determination of acute toxicity is the first step in toxicological investigations of aqueous extract of Conocarpus erectus L., consti tuting a preliminary pharmacognostic, exploring resources manipulated by the population
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