Abstract
• Phytochemical composition and bio potentials of Bolbitis appendiculata (Willd.)K. Iwats was revealed. • High amount of phenol and triterpenoids was observed in acetone extracts of B. appendiculata, tannins and sterols in methanolic extracts of B. appendiculata and flavonoids in chloroform extracts of B. appendiculata. • B. appendiculata crude extracts demonstrated dose dependent anti-inflammatory, anti-diabetic and toxicity activity. • B. appendiculata can be considered as an alternative source for plant-derived anti-inflammatory and anti-diabetic agents . The present study was aimed to reveal the phytochemical composition and bio potentials of Bolbitis appendiculata (Willd.)K. Iwats. The qualitative and quantitative profiles viz., total phenolic, tannin, flavonoid, terpenoids, sterols content of B. appendiculata were determined. To reveal the bioactivity of B. appendiculata extracts, RBC Membrane stabilization heat induced haemolysis, In-vitro alpha-amylase inhibitory assay and Brine Shrimp lethality bioassay were performed. Among the tested extracts, acetone extracts of B. appendiculata illustrated high amount of phenol and triterpenoids than other studied extracts and methanolic extracts of B. appendiculata displayed maximum amount of tannins and sterols than other studied extracts. Highest amount of flavonoids was observed in chloroform extracts of B. appendiculata . All the studied extracts of B. appendiculata demonstrated dose dependent anti-inflammatory, anti-diabetic and toxicity activity. The anti-inflammatory activity of the B. appendiculata was as follows: petroleum ether > acetone > methanol > chloroform. The anti-diabetic properties of the B. appendiculata (25 µg/ mL) was as follows: acetone (56.12 %) > chloroform (37.96 %) > methanol (36.86 %) > petroleum ether (34.56 %). The toxicity of the B. appendiculata was as follows:petroleum ether > chloroform > methanol > acetone . The observed results of B. appendiculata extracts suggested that B. appendiculata can be considered as an alternative source for plant-derived anti-inflammatory and anti-diabetic agents . Further studies may bring out the active principles with anti-inflammatory and anti-diabetic potentials.
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