Abstract
The genus Raputia Aubl. comprises 10 species of neotropical Rutaceae in the subtribe Cuspariinae. R. simulans Kallunki occurs in the upper Amazon basin of Brazil, Colombia and Peru [1]. Due to the rarity of the genus and the complicated taxonomy amongst similar genera (Raputia and Neoraputia), no actual phytochemical study of the genus Raputia has been reported so far. We report herein the investigation of the dichloromethane extract of the roots of R. simulans, which has led to the isolation of mainly indole type alkaloids. The isolation procedure was performed using HPLC and sephadex columns while the structure determination was based on 1D and 2D NMR experiments. Both monomers and dimers were isolated, bearing one and two indole moieties, respectively. Bisindole alkaloids appear to be common in some tropical plants of the Annonaceae and the Rutaceae family [2] [3]. One new simple indole with a non-fused furane ring was isolated, 5-(4-(methoxymethyl)furan-2-yl)-1H-indole (1), along with the previously isolated 7-(3-Methyl-2-butenyl)-1H-indole (2) [4], and the indole-5-carbaldehyde (3). The latter is referred as natural product for the first time.
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