Abstract
Phytochemical investigation of n-butanol fraction of Kigelia pinnata leaves lead to the isolation of six known compounds. Among them two compounds polybotrin (4), scutellarin 7-O-β-D-glucopyranoside (6) have been isolated for the first time from this plant. The structure of compounds was elucidated by extensive spectroscopic methods, including one-dimensional, two-dimensional nuclear magnetic resonance experiments, and mass spectrometry analysis. All the isolated compounds (1–6) were assessed for osteogenic activity in primary calvarial osteoblast cultures. Compound 6 increased alkaline phosphatase activity and mineralization at 10 nM and 1 μM concentrations, respectively.
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