Abstract
Ethanolic extract of stem bark of Coscinium fenestratum was investigated for hepatoprotective activity against CCl4 induced liver damage. Various biochemical parameters were studied to evaluate the hepatoprotective activity of crude extract. Serum total bilirubin, total protein, AST, ALT and ALP were determined to assess the effect of the extract on CCl4 induced hepatic damage. The study was also supported by histopathology of liver sections. Results of this study revealed that the serum markers in animals treated with CCl4 showed elevated concentration indicating severe hepatic damage. Blood samples from the animals treated with ethanolic extract showed significant reduction in the serum markers indicating the effect of plant extract in restoring the normal functional ability of the hepatocytes. Two doses of extract tested, hepatoprotective activity was more pronounced at the dose of 100mg/ml. This study reveals that ethanolic extract of C.fenestratum could afford a significant protection against CCl4 induced hepatocellular injury.
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