Abstract
Context: Despite some studies related to the Rhododendron arboreum, phytochemical analysis remained unexplored. Potential cytotoxic, antibacterial and enzyme inhibitory activities relevant to traditional knowledge system were examined and LC-MS was performed to investigate the chemical composition. Material and Methods: The chemical composition of two fractions in ratio of 70:30 and 50:50 in methanol were determined by Liquid Chromatography coupled with Mass Spectroscopy (LC-MS). Antioxidant activity of methanol extract of both sample were determined by DPPH, FRAP and antibacterial assay were investigated. Results and Discussion: The main constituents were cis- retinoic acid, phytol, kempferol-3,4,7-tri-O-sulfate, 6-β-D-xylopyranosylluteolin, mucronulatol. Fraction second exhibit strong antioxidant and antibacterial activity (IC50 = 20.1μg/mL) compared to the ascorbic acid and BHT as well as highest FRAP (IC50 = 28.4μg/mL). The flavonoid were identified in these fractions using LC-MS analysis as quercetin O-β-glycoside. Conclusion: This study provides scientific report to uses of R. arboreum found in North India. Thus, the present study showed that the flowers contain bioactive compounds with good antioxidant activity for pharmaceutical and pharmaceutical applications.
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