Abstract
The devastating occurrence of drug resistance such as antimicrobial resistance has aroused global concerns for public health, which has propelled a continuous pursuit of safe and effective therapeutic agents. In this study, silver nanoparticles were decorated in mesoporous silica of SBA-15 coated with melanin-like polydopamine (PDA) as nanocarriers. Meanwhile, the constructed mesopore was loaded with phytochemical curcumin (CCM) through its noncovalent interactions with PDA coatings. The obtained CCM@SBA-15/PDA/Ag composites were characterized by physicochemical methods and exhibited desirable biocompatibility and low hemolytic activity. The dual-stimuli-responsive (pH and ROS) release of curcumin and/or silver nanoparticles from the CCM@SBA-15/PDA/Ag composites was achieved to reduce the side effects of noncontrolled drug leakage under physiological conditions. Additionally, compared with that of SBA-15/PDA/Ag and CCM@SBA-15/PDA, CCM@SBA-15/PDA/Ag combination showed a prolonged inhibitory effect on bacterial growth of G–E. coli (72 h) and G+S. aureus (24 h), attributing to the enhanced effect of the bactericide of silver nanoparticles and curcumin. Furthermore, through the utilization of the nanoformulation of curcumin, improved chemotherapeutic efficiency against human cervical cancer cells (HeLa) and Taxol-resistant nonsmall cell lung cells (A549/TAX) was identified in comparison with that of free curcumin. Thus, our study rationalized the combinational design of the natural compound and silver nanoparticles as an integrated dual-responsive nanoplatform in dealing with infectious bacteria and drug resistance in cancers for enhanced therapy.
Highlights
In recent years, the spread of drug resistance has become a global concern.[1,2] For example, the bacteria that resist antibiotics were framed as the most threatening types to the public health by the World Health Organization (WHO).[3]
Melanin-like biopolymers commonly exist in the human tissues and organs including hair, skin, and brain medulla,[18] which were widely used in the fields of biosensing, diagnosis, and tissue engineering due to their superior biocompatibility and biodegradable nature.[22−27] Among melanin-like biopolymers, polydopamine (PDA) possessed remarkable interfacial reinforcement when adhered to diverse types of material surfaces due to the abundant amine and/or catechols.[28−30] PDA-based surface modification nanoplatforms have been investigated widely in the field of biomedicine due to the pH, reactive oxidative species (ROS), and near-infrared (NIR) multiresponsive properties.[8,31]
The PDA film was formed by the polymerization of dopamine on the inner surface of mesopores and the outer surface of Santa Barbara Amorphous-15 (SBA-15) and the silver nanoparticles were in situ reduced and deposited on the PDA film
Summary
The spread of drug resistance has become a global concern.[1,2] For example, the bacteria that resist antibiotics were framed as the most threatening types to the public health by the World Health Organization (WHO).[3]. Melanin-like biopolymers commonly exist in the human tissues and organs including hair, skin, and brain medulla,[18] which were widely used in the fields of biosensing, diagnosis, and tissue engineering due to their superior biocompatibility and biodegradable nature.[22−27] Among melanin-like biopolymers, polydopamine (PDA) possessed remarkable interfacial reinforcement when adhered to diverse types of material surfaces due to the abundant amine and/or catechols.[28−30] PDA-based surface modification nanoplatforms have been investigated widely in the field of biomedicine due to the pH, reactive oxidative species (ROS), and near-infrared (NIR) multiresponsive properties.[8,31] Typically, nanocarriers coated with PDA are utilized for controlled drug release and photothermal therapy on tumor cells.[32,33] Under mild alkaline conditions, the aromatic hydroxyl moieties of PDA can promote the stable formation of metal nanoparticles without the addition of other reducing agents.[34−36] PDA with plentiful aromatic rings on the surface enabled a high payload of therapeutic molecules such as curcumin via π−π stacking and/or hydrogen bonding.[37,38] The built nanoformulation of PDA layers combined with curcumin may endow the therapeutic excipients with a smart function, including the acid- and/or reactive oxidative species (ROS)triggered release of loaded drugs, which was expected to improve the bioavailability of curcumin for the purpose of targeted and controlled therapy. This mesoporous melanin-like PDA with silver nanoparticle deposition and curcumin encapsulation provided a promising and effective combination therapy to combat the growth of infectious bacteria and cancer
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