Abstract
Phytochemical Constituents and Antioxidant Potential of Crude Extracts from Lippia Javanica (Burm.f.) Spreng Leaves
Highlights
Oxidative stress is considered as the aetiology of life threaten diseases including cardiovascular diseases, diabetic, renal diseases, cancer, inflammatory diseases and neurodegenerative diseases.[1]
All the crude extracts showed differ degrees of antioxidant potential as evidence by significantly (P < 0.05) scavenging diphenyl-2-picryl hydrazyl (DPPH), ABTS and nitric oxide (NO) radicals, Acetone crude extract showed the lowest IC50 (2.22 × 10-3 and 2.42 × 10-3 mg/ml) toward DPPH and ABTS radical respectively in comparison to other crude extracts, and the positive controls (Ascorbic acid and Butylated hydroxyl anisole), Hexane crude extract showed the lowest IC50 (3.95 × 10-1 mg/ml) toward NO radical compared with other treatments
Conclusion: this study proves that Lippia Javanica crude extracts are good source of natural antioxidants in alleviating oxidative stress diseases
Summary
Oxidative stress is considered as the aetiology of life threaten diseases including cardiovascular diseases, diabetic, renal diseases, cancer, inflammatory diseases and neurodegenerative diseases.[1]. Objectives: This study evaluated the phytochemical constituents and antioxidant activity of Lippia Javanica’s crude extracts. Crude extracts were prepared using various solvents (hexane, acetone, ethylacetate, methanol, dichloromethane respectively), and percentage yields calculated. The antioxidant activities of crude extracts were monitored with DPPH, ABTS and nitric oxide (NO) radicals using spectra techniques. Percentage yield increased in order; Acetone > Methanol, > Dichloromethane > Ethyl-acetate > Hexane. Conclusion: this study proves that Lippia Javanica crude extracts are good source of natural antioxidants in alleviating oxidative stress diseases.
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