Abstract
In this research paper, we investigated the effect of Euphorbia bivonae extract compounds on the lethality of brine shrimp Artemia salina and on the embryonic cell line (HEK293) proliferation. Our GC/MS analysis revealed that the E. bivonae ethanolic extract contained essentially sitsoterol, euphol and lupeol. The 24-h LC50 was determined using the probit analysis method (LC50= 357.11mg l-1). Depending on this cytotoxicity test result, E. bivona extract induced a significant increase of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione-Peroxidase (GPx) activities, and lipid peroxidation (LPO) in A. salina larvae. In addition, the cytotoxicity effect of this extract had proved against the HEK293 cell line in vitro. We suggest that the three compounds of E. bivonae extract (sitsoterol, euphol and lupeol) are the most responsible for this cytotoxicity. The possible application of this extract as an alternative natural antiproliferative is considered.
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