Abstract
Objective: Both honeybees (Apis spp.) and stingless bees (Trigona spp.) produce honeys which normally taken orally, have high nutritional and therapeutics value. Until recently, phytochemical comparison of both honey is still scarce and elucidating cytotoxicity effects on human gingival fibroblast cells (HGF) in oral cavity is of interest. Materials and Methods: Kelulut honey (KH), acquired from the stingless bees and acacia honey (AH) from the sting bees honey samples were underwent GC-MS analysis to ascertain their composition. HGF were exposed to various concentrations of KH and AH from the lowest 0.015% to the highest 5% by MTT assay for 24h, 48h and 72h. Results: GC-MS analysis determined various beneficial compounds such as flavonoids, furans, pyrans, levoglucosan and hydroxymethylfurfural from both of honey samples. MTT assay showed that the HGF cells demonstrated good viability up to percentages (v/v) as high as almost 2% in both honeys. The IC50 values for both honey for all time frames fall at above 2%. Conclusion: Both honey showed good survivability of HGF cells up to 2% of concentration. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 158-164
Highlights
Synthetic drugs are the most common form of therapeutics to be used for various medical conditions[1]
Due to the importance role of honey in the use of traditional medicine, numerous investigations were performed by different researchers throughout several decades culminating to its place in modern medicine[8].Until now, studies have been conducted to ascertain the properties of honey from different parts of the world as an antibacterial9,10,11,12,13,14,15,16. capability to overcome gastrointestinal[17], cardiovascular[18] and, liver problems[19], possess properties within its natural composition that
Kelulut honey (KH) was identified with furfural compounds which are furan derivatives, hemiterpenoids, levoglucosan, flavonoids and naturally occurring ketones
Summary
Synthetic drugs are the most common form of therapeutics to be used for various medical conditions[1]. For oral conditions, they play a major role in the promotion of good oral health and wellness, from treatment of various oral diseases to good daily oral hygiene maintenance[2]. AH, product of a sting bee variety is known for its pale-yellow colour, herbaceous and delicate flavour[3]. These both honey varieties have shown in various studies to have medicinal potential[4,5,6,7]. Due to the importance role of honey in the use of traditional medicine, numerous investigations were performed by different researchers throughout several decades culminating to its place in modern medicine[8].Until now, studies have been conducted to ascertain the properties of honey from different parts of the world as an antibacterial9,10,11,12,13,14,15,16. capability to overcome gastrointestinal[17], cardiovascular[18] and, liver problems[19], possess properties within its natural composition that
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