Abstract
BackgroundCousinia Cass. is one of the most diverse genus of Asteraceae family. According to previous studies some Cousinia species showed significant cytotoxic activity. PurposeIn this study, we aimed to investigate the cytotoxic activity and phytochemical profile of four Cousinia species (C.davisiana Hub.-Mor., C.foliosa Boiss. & Balansa, C.ramosissima DC, C.stenocephala Boiss). MethodsThe cytotoxic activity was investigated with SRB method against HepG2 (human hepatocellular carcinoma) cell line. The quantitative and qualitative determination of compounds were carried out by LC-MS/MS. ResultsIn a result, C. davisiana methanol extract (CD) and ethyl acetate sub-extract (CDE) showed more cytotoxic activity with 150 and 89 µg/ml IC50 values, respectively. The mass spectrums revealed the presence of 15 compounds in CD methanol extract and 9 compounds in active CDE sub-extract. According to quantitative analyses the highest contents of all compounds were detected in CD extract. ConclusionMoreover, this study on inhibitory activity of CD extract and CDE sub-extract suggests detailed investigation for cytotoxic activity.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
