Abstract
Ulva lactuca is widespread green algae. In some regions, it is used in nutrition. Its nutrients include iron, protein, iodine, vitamins (A, B1, and C) and trace elements. Their extracts showed potential antibacterial, hypolipidemic, cardioprotective and chemoprotective activities. The main chemical constituents of Ulva lactuca methanolic crude extract and its fractions were investigated in this study using different phytochemical and chromatographic methods. Biologically guided fractionation of plants or seaweeds extracts is considered the first step in drug discovery. So, the algal crude extract was fractionated then in vitro bioscreened for the determination of diphenylpicrylhydrazyl (DPPH) antioxidant, (Nitric Oxide) NO radical scavenging and anti-inflammatory activities. Results showed that water fraction was the most active fraction. Phenolic content, detected from HPLC, play a role in the antioxidant activity. Finally, it can be concluded that Ulva water fraction is effective candidate to be used in the treatment of oxidative stress and related disorders
Highlights
Green algae are the most diverse group of algae with more than 7000 species growing in a variety of habitats
Ulvan extracted from the algae showed cytotoxic activity (Thanh et al, 2016) while the aqueous ethanolic extract showed chemoprotective effect (Delgado-Roche et al, 2019)
The blood was collected from healthy human volunteer who had not taken any anti-inflammatory drugs for 2 weeks prior to the experiment and transferred to the heparinized centrifuge tubes and centrifuged at
Summary
Green algae are the most diverse group of algae with more than 7000 species growing in a variety of habitats. Ulva lactuca is a widespread macro alga occurring at all levels of the intertidal zone. In some regions, it is consumed in nutrition. This is associated with various chronic diseases (Cooke et al, 2002). For these reasons, antioxidant compounds are widely used to minimize oxidative damage. The aim of this study was to investigate the crude methanolic extract obtained from the Egyptian Ulva lactuca and its different fractions using phytochemical and chromatographic methods and evaluate their in vitro antioxidant and antiinflammatory properties in order to identify and utilized effective new sources of antioxidants of natural origin
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