Abstract
The fresh juice from leaves of Sedum dendroideum Moc & Sessé (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1–1 g/kg) of the lyophilized Sedum dendroideum juice (LJ) caused a significant dose-related reduction of acetic acid-induced writhing response (ID 50 = 631 mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1 g/kg) in mice. In the formalin-induced nociception in mice, LJ (1 g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
