Abstract
BackgroundTraditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. This study aims at the investigation of the phytochemical and pharmacological properties of the ethanol extract of this herb.MethodsFresh whole plant was extracted with absolute ethanol. A preliminary phytochemical investigation was followed by the evaluation of thrombolytic, anti-inflammatory, and anti-nociceptive activities by applying human clotted blood lysis, egg albumin, and acetic acid-induced writhing models, respectively.ResultsPhytochemical investigation suggests that B. pilosa possesses alkaloids, flavonoids, glycosides, terpenoids, tannins, saponins, and reducing sugars. The extract exhibited clot lysis and anti-inflammatory effects in a concentration-dependent manner. B. pilosa extract at 250 and 500 mg/kg also showed significant (p < 0.05) dose-dependent anti-nociceptive activity in Swiss albino mice.ConclusionThe B. pilosa ethanol extract contains many important secondary metabolites and has thrombolytic, anti-inflammatory, and anti-nociceptive activities. More research is necessary on this hopeful medicinal herb.
Highlights
Medicinal plants still remain a potential source of modern therapeutic agents for various diseases [51]
The results suggest that B. pilosa ethanol extract contains many important secondary metablies, including alkaloids, flavonoids, glycosides, terpenoids, tannins, and saponins
We found diverse secondary metabolites in B. pilosa extract, suggesting a strong foundation for further studies aiming to isolate anti-inflammatory lead compounds from this medicinal herb
Summary
Medicinal plants still remain a potential source of modern therapeutic agents for various diseases [51]. It may be due to their low side effects and high safety profile in experimental animals and humans [13]. Plant-derived compounds are beneficial for designing new chemical entities in the drug discovery and development processes. In the drug discovery and development context, the bioactivity of plants or their parts such as leaves, stems, and roots frequently used in traditional medicine is Byttneria pilosa Roxb. Scientific reports suggest that it has significant antiinflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. This study aims at the investigation of the phytochemical and pharmacological properties of the ethanol extract of this herb
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