Abstract
Clematis L. (Ranunculaceae) is a genus of about 300 species widespread throughout the world. Many Clematis species are traditionally used for various ailments, among them many diseases related to inflammation. As a part of a phytochemical and pharmacological study of Clematis species, extracts of the upper parts of C. mandshurica Ruprecht, C. vitalba L. and C. integrifolia L. were tested for anti-inflammatory activity in vitro. At a concentration of 50µg/ml, the ethanol extracts in general showed much better inhibition on LPS-induced IL-8 expression in HUVEC-Tert cells than the dichloromethane extracts, with 78.2±3.1% (C. man), 80.8±9.0% (C. vit) and 80.6±2.9% (C. int) inhibition. LC-DAD-MSn analysis was performed for phytochemical profiling of the tested extracts. The chemical profiles showed big variation between species, e.g. major differences were observed regarding phenolic constituents and triterpenes. Differences were also observed in the phytochemical and pharmacological analysis of leaves and stems of the three species.
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