Abstract
The main aim of the present work was to perform phytochemical screening and evaluation of anti-hyperglycaemic properties of Gynandropsis gynandra root extract in normal and alloxan induced diabetic rats. G. gynandra root was characterized for phytochemical characteristics. G. gynandra root gave maximum extractive values of 6.4 w/w with methanol; and the loss on drying value, total ash value, acid-insoluble ash and water soluble ash values were within limits. The methanolic extract gave total solid content of 91.96% w/w. The extract gave positive tests for phytosterols, triterpenes, flavonoids, carbohydrates and alkaloids. The extract was free from glycosides, saponins, tannins, proteins and amino acids. A single oral administration of alcoholic extract at doses 100, 250 and 500 mg per kg produced a significant blood glucose reduction in a dose dependent manner in normal and diabetic rats. These data confirm the hypoglycaemic and anti-hyperglycaemic effect of alcoholic extract of G. gynandra root in normal and diabetic rats respectively when compared with standard drug Tolbutamide.
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