Abstract
Chromatographic fractionation and chemical investigation of the methanolic extract of the fronds and rhizomes of Adiantum capillus-veneris L. (Pteridaceae), resulted in the isolation and identification of four compounds. The structures of the isolated compounds were elucidated using ESI-MS, 1D and 2D (COSY, HSQC and HMBC) NMR experiments, as well as by comparison with literature data. The isolated compounds were identified as; pinoresinol 4-O-β-d-glucopyranoside (1), pterosterone (2), kampferol-3-O-β-d-glucuronide (3), and quercetin-3-O-β-d-glucoside (4). Compounds 1 and 2 are reported here to be isolated for the first time from family Pteridaceae, however compounds 3 and 4 were isolated previously from the plant. Total methanolic extract as well as n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions of A. capillus-veneris L. fern were evaluated for their antidiabetic and anti-yeast activity. The four isolated compounds were also evaluated for their anti-yeast activity. The ethyl acetate fraction showed the highest antidiabetic activity. Its inhibitory activity against both α-glucosidase and α-amylase enzymes was with IC50 values of 52.8 µg/ml and 62.4 µg/ml, respectively. The n-hexane fraction showed the highest anti-yeast activity.
Highlights
A. capillus-veneris is a delicate, perennial fern, with a creeping rhizome
The main objective of the present work is to investigate the phytoconstituents, isolation and structure elucidation of the isolated compounds and biological evaluation of A. capillus-veneris growing in Egypt
Its molecular formula was established to be C26H32O11 from the [M+Na]+ ion at m/z 543, in the electrospray ionization (ESI)-MS
Summary
A. capillus-veneris is a delicate, perennial fern, with a creeping rhizome It is often found growing on limestone cliffs away from direct sunlight and out of the way of drying southwest winds (Al-Snafi, 2015). The fresh or dried leafy fronds had been used as antidandruff, antitussive, astringent, demulcent, depurative, emetic, weakly emmenagogue, emollient, weakly expectorant, febrifuge, galactagogue, laxative, pectoral, refrigerant, stimulant, sudorific and tonic (Ansari and Ekhlasi-Kazaj, 2012; Nazim et al, 2018) It is effective with female conditions and is used to regulate menstruation, dysmenorrhea, and facilitate childbirth (Ansari and Ekhlasi-Kazaj, 2012; Nazim et al, 2018). Compounds 1 and 2 are reported here to be isolated for the first time from family Pteridaceae
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