Abstract
Two triterpenoids, lupeol (1) and stigmasterol were isolated from the petroleum ether soluble fractionof the methanolic extract of Ixora lutea Hutch. In our preliminary screening, the petroleum ether, carbontetrachloride, chloroform soluble fractions of methanol extract of the leaves and stem were subjected to antioxidant,antimicrobial and brine shrimp lethality bioassay. All of the fractions showed moderate to potent antioxidant activity,of which the chloroform soluble fraction demonstrated the strongest antioxidant activity with the IC50 value of 3.0μg/ml. In case of antimicrobial screening, all extractives showed mild growth inhibitory activity. However, in thebrine shrimp lethality bioassay, the petroleum ether soluble fraction was found to be most cytotoxic among thepartitionates having LC50 value 0.938 μg/ml.Key words: Ixora lutea; rubiaceae; lupeol; stigmasterol; antioxidant activity; brine shrimp lethality bioassay;antimicrobial.DOI: 10.3329/dujps.v8i1.5331Dhaka Univ. J. Pharm. Sci. 8(1): 17-21, 2009 (June)
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