Abstract
Seven compounds, turmeronol-A (1), turmeronol-B (2), 3,4-dimethoxycinnamic acid (3), 4-hydroxy-3-methoxycinnamic acid (4), 4-hydroxybenzaldehyde (5), 2,3,5,6-tetrahydroxyarturmerone (6) and 4-hydroxybisabola-2,10-diene-9-one (7) have been isolated from the carbon tetrachloride soluble fraction of a methanol extractof the rhizomes of Curcuma longa. Careful interpretation of the NMR data and comparison with turmeronol A (1)allowed tentative identification of compound 6 as 2,3,5,6-tetrahydroxy-arturmerone, which appears to be a newmolecule. The n-hexane, carbon tetrachloride and chloroform extractives of the rhizomes when subjected toantimicrobial screening and brine shrimp lethality bioassay demonstrated mild to moderate antimicrobial activity andstrong cytotoxicity with LC50 value 1.56 μg/ml.Key words: Curcuma longa; Zingiberaceae; turmeronol-A; turmeronol-B; 2,3,5,6-tetrahydroxy-arturmerone and 4-hydroxybisabola-2,10-diene-9-one; antimicrobial; cytotoxicity.DOI: 10.3329/dujps.v8i1.5334Dhaka Univ. J. Pharm. Sci. 8(1): 39-45, 2009 (June)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
