Abstract
The in vitro and in vivo antimicrobial activities of the methanolic leaves extract of Paullinia pinnata were evaluated. The phytochemical analyses revealed the presence of alkaloids, cardenolides, anthraquinones and tannins. The killing kinetic showed that the plant extract eliminated Pseudomonas aeruginosa (4 hr at 800 mg.mL−1) and Staphylococcus aureus (8 hr at 400 mg.mL−1). Groups A-C were infected and treated with 800, 400, and 200 mg.mL−1 of the plant extract with no observable tissue damage. Group D was infected but not treated and histopathological analysis of the organs showed some tissue damages. Paullinia pinnata could be a good alternative in the treatment of infections caused by these organisms.
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