Phytochemical and Anti-Inflammatory Potential of Anredera cordifolia (Ten): A Review

Abstract

Objective : Inflammation is a manifestation of the immune response to eliminate antigens from the body. This process will occur until the antigen is eliminated from the body. This inflammatory process can occur locally or systemically. Anredera cordifolia (Ten) has been used as a traditional medicine as a therapy for inflammation, diabetes, kidney failure, hypertension, hyperlipidemia, and others. Therefore, this review aims to provide current information and obtain a comprehensive review of the anti-inflammatory activity of Anredera cordifolia (Ten).
 Methods : This review provides evidence in the literature for the phytochemical and anti-inflammatory activity of Anredera cordifolia (Ten), from August 2011-August 2021. Three bibliographic databases were used as the main sources of information (Pubmed, ScienceDirect, and Google scholar). The keywords used in this research are as follows: “Phytochemical”, “anti-inflammatory”, “Bioactive compounds”, “Pharmacology” and “Anredera cordifolia”.
 Results: A total of 10 studies were included in this review according to the required criteria, 5 of which were concerning phytochemical and 5 were concerning anti-inflammatory. Anredera cordifolia (Ten) contains many secondary metabolites such as essential oil, saponins, phenolics, rauninflammatory activity of Anredera cordifolia (Ten) occur mainly through several mechanisms including a decrease in the volume of paw edema, inhibition of hemolysis, inhibition of the inflammatory mediators TNF-α, IL-1β, IL-6, and NO, and a decrease in the number of neutrophil PMNs.
 Conclusions: Recent interest in the traditional treatment of the Anredera cordifolia (Ten) plant both in vitro and in vivo has shown potential anti-inflammatory activity attributed to the presence of natural bioactive compounds.
 Keywords : Anti-inflammatory, Anredera, Phytochemical, Pharmacology