Phytochemical analysis of Ipomoea involucrate

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We have recently reported that methanolic extracts from Ipomoea involucrata P. Beauv. (Convolvulaceae) exhibited particular antisickling properties coupled with the potential to reverse sickled blood and reduce stress in sickle cell patients1. In light of its possible medicinal benefits the MeOH plant extract was analysed for twenty bioactives by high performance liquid chromatographic (HPLC) equipped with UV-detector. Chlorogenic acid (33.72±0.24 mg/g. dry wt. leaves), ferulic acid (15.60±3.46 mg/g. dry wt. leaves), hesperidin (6.71±1.57 mg/g. dry wt. leaves), lutein (2.55±0.09 mg/g. dry wt. leaves), resveratrol (2.54±0.28 mg/g. dry wt. leaves), coumaric acid (1.75±0.17 mg/g. dry wt. leaves), myricetin (1.70±0.00 mg/g. dry wt. leaves), kaempferol (0.93±0.71 mg/g. dry wt. leaves) and rutin (0.80±0.43 mg/g. dry wt. leaves) were the nine bioactives detected. The high levels of the major compounds (chlorogenic acid, ferulic acid and hesperidin) were similar to that of leaves of other Ipomoea sp.2-4 Hesperidin was first reported in this study among the Ipomoea sp. The leaves has relatively higher levels of coumaric acid than I. mauritiana; ferulic acid, resveratrol and lutein than I. batatas; and similar levels of myricetin to that in I. batatas.2,5-6 Ferulic acid in I. hederacea, myricetin in I. aquatica, rutin in I. batatas; and coumarin in I. cairica, Ipomoea digitata L., Ipomoea hederacea, I. pes-caprae , I. pes-tigridis, I. sepiaria and I. batatas were also detected but not quantified.3 The identified compounds could significantly contribute to the medicinal properties of the plant.3 A future investigation will carry out to evaluate the antisickling properties coupled with the potential to reduce stress in sickle cell patients of the isolated constituents.