Abstract
The current investigation was designed to assess the preliminary phytochemical analysis, antimicrobial and anti-radical effect of crude methanolic extract and isolated fractions of Nigella sativa seeds using established protocol. The phytochemical analysis revealed the presence of alkaloids, terpenoids, tannins, reducing sugars, saponins, steroids, proteins and amino acids, fatty acids and caumarine. The crude methanolic extract and isolated fraction were subjected to antibacterial, antifungal and antioxidant activities. The ethyl acetate and chloroform fractions demonstrated significant (80% and 78%) antioxidant activity. Regarding antibacterial activity of N. sativa, chloroform fraction showed good antibacterial effect as compared to the rest of solvent extracted fractions. Fractions were tested for antifungal activity as well. Amongst all, MeOH fraction showed good antifungal activity against A. N and A. S. n- Hexane showed no activity while other fractions showed moderate activity. The current finding suggests that N. sativa contains potential molecules which exhibited excellent antioxidant and antibacterial effect.
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