Abstract
<i>In vitro</i> antifungal activity of leaf extract of five invasive plant species were evaluated against the fungal pathogen <i>Macrophomina</i><i> </i><i>phaseolina</i> using Microdilution assay and direct bioautographic technique. Plants selected for investigations were <i>Ageratum conyzoides</i>, <i>Antigonon</i><i> </i><i>leptopus</i>, <i>Chromolaena</i><i> </i><i>odorata</i>, <i>Oxalis corniculata</i> and <i>Passiflora</i><i> </i><i>foetida</i>. Methanolic extract of all the plants exhibited good activity with minimum inhibitory concentration (MIC) values ranged between 0.078- 2.5mg/ml. The leaf extract of <i>Oxalis corniculata</i> had promising antifungal activity with a low MIC value of 0.078mg/ml compared to the other species extracts tested. Total activity was highest in <i>Antigonon </i><i>leptopus</i>(2304ml/g) followed by <i>Oxalis corniculata</i>(2141ml/g). Bioautography indicated clear zones of inhibition in <i>Antigonon</i><i> </i><i>leptopus</i> extract with three active band at R<SUB>f</SUB> value of 0.779, 0.468 and 0.276 in BEA mobile system and fungal growth was inhibited in most of the plants tested.
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