Abstract
Jasminum mesnyi Hance (yellow jasmine, Family Oleaceae) belongs to an important subclass of Jasminum family whose biological significance is under explored. The current study pertains to isolation of various solvent extracts fractions and their anti-bacterial effects on the Gram-positive and Gram-negative bacterial pathogens. Ethanolic extract of J. mesnyi Hance leaves was subjected to further partitioning using different solvents with increasing polarity to get different solvent fractions. Different extracts were analysed for their phytochemical constitutents and were evaluated for their antibacterial activity against a number of diseases causing bacteria. Diethylether fraction (DEF) showed remarkable inhibition of growth of Aeromonas hydrophila and Vibrio parahaemolyticus with inhibition zones of 17 and 19mm, respectively at 250 μg. On the other hand, the hexane fraction (HF) was found to be more effective against Gram- positive test bacterial pathogens (Bacillus anthracis and Bacillus subtilis) with inhibition zones of 19.6 mm and 17.5 mm, respectively. The phytochemical screening of different test fractions revealed the predominant presence of cardiac glycosides, sterols and terpenoids in DEF and HF, while Ethylacetate fraction (EAF) and methanol fractions (MF) were found rich in flavonoids and phenols with moderate amount of other reference metabolites.
Highlights
IntroductionBacterial diseases top the list of infectious diseases caused by biotic agents
Many human and animal diseases arise due to either bacterial or viral infections
According to the Centers for Disease Control and prevention, at least 2 million people become infected with antibiotic resistant bacteria every year in the United States only, of which approximately 25,000 people die each year as a direct result of these infections [3]
Summary
Bacterial diseases top the list of infectious diseases caused by biotic agents. While several such infections may be treated or controlled by antibiotics, their indiscriminate use has resulted in bacterial adaptation to these molecules and antibiotic resistance. Emergence of antibiotic resistant strains and adverse effects of the existing antibiotics has become a potential hurdle in the treatment of infectious diseases. This necessitates the search for new antimicrobial molecules/agents that may efficiently overcome the drug resistance problem as well as alleviate the adverse effects of currently employed antibiotics [4]. Natural products derived from various life forms including microorganism, plant, and animal are endowed with excellent properties like chemical diversity, structural complexity, affordability, and lack of substantial toxic effects
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