Abstract
PULICARIA UNDULATA is one of the aromatic annual herbs used in folk medicine in Egypt. The aerial parts of P. undulata plants were collected from the Red sea coastal desert during the flowering stage and used for phytochemical analysis. It was revealed that P. undulata aerial portions contain phenols, flavonoids terpenoids, saponins, alkaloids, glucosinolates and cardiac glycosides highlighting its participation in drug development and using as an alternative strategy to the harmful synthetic fungicides. The greater accumulation of the bioactive compounds in the methanolic extract was comparable with its higher antioxidant capacity and IC50 value as compared with those of the petroleum ether extract. The GC-MS analysis revealed the occurrence of ten bioactive phytocomponents including cyclotrisiloxane, hexamethyl-, cyclotetrasiloxane, octamethyl-, cyclopentasiloxane, decamethyl, dodecanoic acid, methyl ester, tetrafluorophthalonitrile, gamma-Sitosterol, nonacosane, 4,4,6a,6b,8a,11,11,14b-Octamethyl ,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydro-2H-picen-3-one, thiazolo[4,5-f]quinoline and 7-methyl-. In addition, the methanolic extract exhibited antifungal activity against the investigated six pathogenic fungal strains: Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Microsporum canis, Microsporum boulardii and Trichophyton mentagrophytes. Based on the values of the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC), the methanolic extract has demonstrated a fungicidal effect on M. boulardii IFM 56403, T. mentagrophytes AUMC 11661, M. canis AUMC 11663, and C. albicans AUMC 9142. The cytotoxicity evaluation of the methanolic extract showed safe levels in case of these four fungal strains. The petroleum ether extract, inhibited the tested fungi but with lower efficiency. Our results suggest the promising antifungal activity of P. undulata on medically important fungi.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
