Phyto-therapeutic Potential of Aerial Part of Sida rhombifolia for Anti- Infl ammatory, Antinociceptive, and Antioxidant Activity

Abstract

Background: To investigate the potential of anti-infl ammatory, antinociceptive, and antioxidant activity of diff erent extracts of Sida rhombifolia. Materials and Methods: The successive extraction of dried aerial parts of S. rhombifolia was performed with the help of the soxhlet apparatus by pet. ether, chloroform, acetone, ethanol and water were used as a solvent. Anti-infl ammatory activity was performed using the carrageenin-induced edema model in the rat paw method. Antinociceptive activity was performed using the mouse writhing and hot plate tests. Antioxidant activity was determined through the ability of hydrogen peroxide scavenging. Result: The ethanolic extract (200 mg/kg.) oral showed maximum anti-infl ammatory activity 51.42 (maximum, %inhibition) after 2 hours. The ethanolic extract (200 mg/kg.) oral showed maximum % inhibition of writhing 57.74 for writhing test and 2.15 ± 0.02 time (sec) of jumping for hot plate test. The ethanolic extract of the drug showed high scavenging (59.25%) of hydrogen peroxide. Conclusion: On successive extraction process of aerial parts of S. rhombifolia reported that diff erent ethanolic extracts are more eff ective as anti-infl ammatory, antinociceptive, and antioxidant activity, respectively.