Abstract
Rabbits, cats and rats with permanent intracerebral recording electrodes were acutely poisoned with lethal, or close-to-lethal, doses of diazepam (80–120 mg/kg i.p. or i.v.) and the protective effect of physostigmine, given at the peak of the diazepam coma, was studied by using three parameters of observation: changes in EEG activity, gross behaviour and mortality rate. Physostigmine (0.25–1.50 mg/kg i.v. or i.p.) exerted a surprisingly strong antidote effect in all the three species investigated. It restored pathological EEG alterations and normalized behaviour within a few minutes. Mortality rate was also reduced to a minimum. Peripheral cholinergic blockade by intraperitoneal methylatropine (10–20 mg/kg) given concomitantly with, or prior to, physostigmine application prevented the peripheral parasympathetic excitation due to physostigmine but left the antidote effect unaltered.
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