Physiopathologie du syndrome clinique d’hyperactivité vésicale

Abstract

The pathophysiology knowledge of the overactive bladder syndrome has evolved considerably over the past 20 years. The objective of this work was, from a review of the literature, to synthesize current knowledge on the pathophysiology of the overactive bladder syndrome. A systematic review based on Pubmed, Embase, Google Scholar, was conducted in February 2020 using the keywords "overactive bladder" and "pathophysiology". Four pathophysiological mechanisms involved in the overactive bladder syndrome development can be described. They include the detrusor muscle dysfunction, an urothelial or sub-urothelial origin, a neurological origin and a change in the urinary microbiome. At the same time, it should be noted that all of the pathophysiological mechanisms described above are favored by different clinical conditions such as aging, ischemia, metabolic syndrome, menopause and the dysfunction of other abdominopelvic systems. The pathophysiology of the overactive bladder syndrome is complex and includes several mechanisms most often associated.