Physiopathologie de l’allergie IgE-dépendante

Abstract

IgE-dependent allergy, which is expanding rapidly worldwide, is becoming a real social problem. In 2050, some projections consider that 50 % of children will be affected. This is a typical example of multifactorial disease in which a predisposing genetic background, atopy, encounters multiple changes in our environment related to Western lifestyle. This induces an imbalance of the intestinal microbiota and then the compartment of regulatory T cells and ultimately an excess of Th2 lymphocytes. This will result in the formation of allergen-specific IgE-secreting plasma cells, followed by sensitization of mast cells and basophilic polynuclear cells. In a second time, the eosinophilic polynuclear will be recruited in their turn.