Physiology study for effecting of radon gas on some hormones of female rats

Abstract

Background: Radium-226 and its daughters, such as radon-222 gas, are harmful elements to the human body it is considered a known carcinogen. The present study aimed to determine the physiological effect of radon gas (radium-226 source) on female rats and included the study of some hormone changes. Methods: The study was done on 25 animals aged (8-12) weeks and the weight of (132-208) g. Results: The first group of rats were not exposed to radon gas, which is as control group. While other groups of rats, (four groups) were exposed to radon gas at doses 3063.05 Bq, 4546.86 Bq, 5265.65 Bq, and 613.85 Bq, respectively. Conclusion: The result of body weight shows no significance (P>0.05) in the body weight of rats in groups exposed to radon gas in comparison with the control group. In addition, the result of FSH and LH hormones shows a significant decrease (P<0.05) in groups exposed to radon gas in comparison with the control group, while the estrogen is not significant (P>0.05) in groups exposed to radon gas in comparison with the control group. The study showed a significant increase (p ≤ 0.05) in the body weight of rats groups exposed to radon gas (RAD) groups. Furthermore, the study showed a significant decrease (p ≤ 0.05) in hormones (FSH, LH) and a significant increase (p ≤ 0.05) in hormones (Estrogen) of rats groups exposed to radon gas (RAD) groups in comparison with control groups. Keyword: FSH, LH, E2, female rats, and radon gas.