Abstract
In adolescent baboons the intravenous injection of bicuculline induced generalized seizures lasting up to five hours, which sometimes led to brain damage or death. Marked initial rises in arterial and cerebral venous pressure were accompanied by severe metabolic and respiratory acidosis, hyperglycemia, and reduced cerebral arteriovenous (AV) differences for oxygen (O2) and carbon dioxide (CO2). In the second phase of the seizure (+25 to +300 minutes) blood pressure was normal or low, cerebral AV differences for O2 andCO wereenhanced, but cerebral venous oxygen tension was not critically reduced. There was severe hyperpyrexia, and hyperkalemia, and sometimes hypoglycemia. Death was cardiovascular in origin. A behavioral and electroencephalographic recovery could occur within three hours of generalized seizure activity lasting one to two hours.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
