Abstract

The physiologic basis of erection is yet to be clear. Recently, we were able to identify the cavernous nerves which are responsible for erection. Using electroerection in the monkey, we were able to study the physiologic changes that occur during erection and detumescence. Basically, erection is a result of: (1) active relaxation of sinusoidal spaces in the corpora cavernosa, (2) active arteriolar dilatation, and (3) active venous constriction. On the contrary, detumescence is a passive phenomenon.

Highlights

  • Erection is the final common pathway of the integrative synchronized action of psychological, neuronal, hormonal, vascular, and cavernous smooth muscle systems

  • The penile erectile tissue, the cavernous smooth musculature and the smooth muscles of the arteriolar and arterial walls, plays a key role in the erectile process. These muscles are tonically contracted by the sympathetic discharge, and vasoconstrictors secreted by endothelium allowing only a small amount of arterial flow for nutritional purposes

  • Yarnitsky et al.[5] found two types of electrical activity recorded from the corpus cavernosum: spontaneous and activity-induced

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Summary

Previously published in the Digital Urology Journal

Erection is the final common pathway of the integrative synchronized action of psychological, neuronal, hormonal, vascular, and cavernous smooth muscle systems. In this short review we will discuss the advancement of knowledge that the last decade have witnessed

Corpora Cavernosa
Corpus Spongiosum and Glans Penis
Smooth Muscle Physiology
Peripheral Pathways
Autonomic Pathways
Somatic Pathways
Flaccidity and Detumescence
Nitric Oxide and cGMP in Relaxation of Smooth Muscle
Central Neurotransmitters
Intracavernous and Topical Drugs
Centrally Acting Drugs
Full Text
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