Abstract

The physiology of coagulation routes and paths is a cascade of several molecular phenomena and biological events which was classified into two categories based on their phenomena i.e., intrinsic and extrinsic, originated separately, consisting of various factors and features such as fibrinogen, prothrombin, plasma thromboplastin, Hageman factor, Christmas factor, and Stuart-Prower factor, participate in its physiology

Highlights

  • Do platelets and factors of clotting cascade play a part in hemostasis? What is a factor responsible for a potential bleeding disorder? How do laboratory tests do to differentiate coagulation disorders? What methods can be useful to do vascular changes that were observed in the abnormalities, occurred during hemostasis? What are the reasons answerable for the origin of many blood complications i.e., platelet deficiencies, extremes, and dysfunction cooperatively? and in the last, what are the why’s and wherefores inheriting in common disorders of coagulation?

  • Based on physiological responses originating in the hemostasis process, paths and routes of the coagulation cascade identified by their useful physicochemical features that were transformed chemically via versatile biochemical reactions and proceedings according to the needs

  • These findings would be applicable in the context of therapy development suggested for treating disorders of coagulation cascade as well as for defying the hereditary disorders of hemostasis, respectively [6]

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Summary

Introduction

Physiology, Coagulation Cascade: Inherited Disorders, and the Molecular Phenomenon of Alterations in Hemostasis. Do platelets and factors of clotting cascade play a part in hemostasis? The author envisions key steps for an accurate revision of inherited disorders and the underlying molecular phenomenon of alterations in hemostasis.

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