Abstract
This comprehensive and updated Second edition is an impressive contribution to the fundamentals of basic science of the heart. The editor has assembled 48 chapters written by experts and wellknown researchers. Eight new chapters, a precious and timely addition to the first edition, include comprehensive discussions on contractile proteins of cardiac muscle, contractile proteins of smooth muscle, cyclic nucleotides and protein kinase in smooth muscle, calcium-activated ion currents in cardiac muscle, developmental changes in adrenergic modulation, endothelial cell interactions with vascular smooth-muscle cells, myocardial infarction and free radical effects on the heart, and extravascular coronary resistance. The basic factors affecting the function of the normal and diseased heart are evaluated by a comprehensive multidisciplinary approach including membrane biophysics, electrophysiology, physiology, pathophysiology, pharmacology, biochemistry, and ultrastructure. Adroitly written chapters, such as chapter 31 on hormonal cardiac performance, deal with topics of special interest to diabetologists and cardiologists alike. Diabetic cardiomyopathy and
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