Abstract
Physiologically distinct neuronal type in primate cortex.
Highlights
Unlike other physiological systems, the central nervous system (CNS) of primates evolves dramatically from that of other mammal species
We reported a subgroup of human and monkey cortical inhibitory interneurons possessing distinct intrinsic physiological features, but similar features were not found in rodent neocortical neurons [1]
Those neurons could fire a train of persistent action potentials (APs) after each brief single-AP stimulus, we named them persistent-activity neurons (PANs)
Summary
The central nervous system (CNS) of primates evolves dramatically from that of other mammal species. We reported a subgroup of human and monkey cortical inhibitory interneurons possessing distinct intrinsic physiological features, but similar features were not found in rodent neocortical neurons [1]. Unlike other forms of persistent activity that require prolonged burst of APs, the persistent firing in PANs is triggered by brief but stopped by strong stimuli.
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