Physiological sway of aging on oxidative stress and levels of some minerals in diabetes type II of both female and male in Sulaimaniyah city

Maya Al-Samman,Sulaf Mohammed

doi:10.33899/edusj.2020.126325.1031

Abstract

Diabetes is a metabolic disorders disease characterized by the abnormal high levels of blood sugar due to incomplete or relative deficiency of insulin secretion as well as disorders in carbohydrate, lipid and protein metabolism. The study aims to evaluate the physiological effects of aging on oxidative stress and mineral levels in diabetes type II by measuring F.B.S,HbA1c%, levels of a number of important indicators of oxidative stress, level of ferritin ,copper and zinc in the serum. The study included the collecting of 70 blood samples from patients with NIDDM for both sexes in the center of Diabetes and Endocrinology in Sulaimaniyah city. The age of each group in this study ranged between 40-70 years. The study concluded that the rate of both FBS and T.GSH increased with age in diabetic females, the MDA increased with age in diabetic males, and ferritin increased with age in both sexes. Moreover copper decreased with age in diabetics for both sexes.

Highlights

Diabetes is defined as the most common endocrine disorder, or a metabolic disorder characterized by chronic hyperglycemia which affects different organs of the human individual; it reduces age of human beings; and leads to their death [1]
The persistent high blood sugar leads to the occurrence of what is known as hyperglycemia, Which seems to be the induction of several biochemical pathways; these biochemical pathways are responsible for the synthesis of free radicals [2]
Reactive species attack fatty membranes, lipoproteins, and polyunsaturated fatty acids and as a result this process will lead to the production of aldehydes such as Malondialdehyde (MDA) which is the last product of Lipid peroxidation (L.P) that is excessively used as a distinguishing marker of oxidative stress in many studies [2]

Summary

Introduction

Diabetes is defined as the most common endocrine disorder, or a metabolic disorder characterized by chronic hyperglycemia which affects different organs of the human individual; it reduces age of human beings; and leads to their death [1]. The persistent high blood sugar leads to the occurrence of what is known as hyperglycemia, Which seems to be the induction of several biochemical pathways; these biochemical pathways are responsible for the synthesis of free radicals [2]. These are highly reactive chemicals that might be in the form of atoms, molecules, or ions. The human body has many defense systems against harmful reactive species known as antioxidants, chemical or biological agents that save cells and substances occurring within the cells from destruction caused by unsteady molecules known as free radicals ;these free radicals are classified according to the work they manifest and their kind of antioxidant enzymes such as Superoxide Dismutase (SOD). The aim of the current study is to investigate the effect of the biochemical variables with relation to diabetes in males and females according to age

Objectives

Methods

Findings

Conclusion