Physiological status of reproductive age girls under conditions of technogenic impact in the Kola North

Abstract

BACKGROUND: An investigation to determine the reproductive health disorders commonly found in adolescent females residing in the North peninsula of Kola, Russia. Insubstantial studies on the physiological status of the reproductive aged females living in a territory that has become highly polluted due to the dust particles of apatite-nepheline ore, determines the relevance of this study and involves the identification of indicators of premorbid state.
 AIM: To examine the physiological status of reproductive aged females living under chronic stress condition caused by exposure to both anthropogenic as well as Arctic environment with an objective to reveal possible pre-nosological deviations as indicators of premorbid state.
 MATERIAL AND METHODS: We conducted an observational, longitudinal analytic "3 waves panel study (2019, 2020, 2021) involving 54 female students 1620 years old from medical college in the city of Apatity, Russia. Physiological status was assessed in accordance with the content of hypothalamic-pituitary-adrenocortical system hormones, metabolites of lipid peroxidation, antioxidant protection, vitamin D, lipids, and carbohydrates using percentile distribution of indicator values. Significance of the differences was determined by comparative analysis of two dependent variables using the Wilcoxon criterion.
 RESULTS: Deviations from the optimal values of physiological state indicators were revealed in more than 25% of the females, which manifested themselves in increased secretion of adrenocorticotropic hormone, cortisol, thyrotropic hormone, and depleting secretion of somatotropic hormone, thyroxine with reduced content of antioxidant protection enzymes. In 95% of females, hypovitaminosis of vitamin D was detected whereas 50% of females were found with diminished values of low-density lipoproteins.
 CONCLUSION: Pre-nosological deviations of the physiological status in the conditions of technogenic pollution testify to the oppression of the bodys protective systems and are predictors of morbidity and are subject to individual correction.