Physiological limit of the daily endogenous cholecalciferol synthesis from UV light in cattle.

Abstract

The link between UV light (sunlight) and endogenous cholecalciferol (vitamin D3 ) synthesis in the skin of humans has been known for more than a 100years, since doctors for the first time successfully used UV light to cure rickets in children. Years later, it was shown that UV light also had a significant effect on the cholecalciferol status in the body of cattle. The cholecalciferol status in the body is measured as the plasma concentration of 25-hydroxycholecalciferol, which in cattle and humans is the major circulating metabolite of cholecalciferol. Very little is, however, known about the quantitative efficiency of UV light as a source of cholecalciferol in cattle nutrition and physiology. Hence, the aim of this study was to determine the efficiency of using UV light for increasing the plasma 25-hydroxycholecalciferol concentration in cholecalciferol-deprived cattle. Twelve cows deprived of cholecalciferol for 6months were divided into three treatment groups and exposed to UV light for 30, 90 or 120min/day during 28days. UV-light wavelengths ranged from 280 to 415nm and 30-min exposure to the UV light was equivalent to 60-min average summer-sunlight exposure at 56°N. Blood samples were collected every 3-4days and analysed for 25-hydroxycholecalciferol and cholecalciferol. Results showed that increasing the exposure time from 90-120min/day did not change the slope of the daily increase in plasma 25-hydroxycholecalciferol. Hence, it appears that cholecalciferol-deprived dairy cattle are able to increase their plasma 25-hydroxycholecalciferol concentration by a maximum of 1ng/ml/day from UV-light exposure.