Abstract
The aim of this study was to evaluate the physiological effects of tylosin in rats. Tylosin was administered orally to pubertal male and female rats at concentrations of 0.005, 0.2, 10 and 200 mg/kg b.w. for 6 weeks. The overall body and organ weights were recorded. Serum levels of immunoglobulins, haematological values, histopathological lesions in different organs, and gene expression profiles in pituitary glands were investigated. The mean platelet volume was increased, and the monocyte count was decreased significantly in both male and female rats treated with tylosin. Compared to the untreated control, alanine transaminase in both types of rats and total serum bilirubin in female rats were increased significantly with the administration of tylosin (200 mg/kg), however, lactate dehydrogenase in female rats was decreased. The levels of immunoglobulin M were reduced in both male and female rats but immunoglobulin G levels were significantly reduced only in female rats which were treated with tylosin. Cell proliferation- and adhesion-associated genes were expressed more but apoptosis gene expressions were decreased in the pituitary gland of tylosin-treated rats. In conclusion, this study revealed that the use of tylosin at therapeutic dosage is possibly not completely safe.
Highlights
Tylosin is one of the most commonly used macrolide antibiotics in veterinary medicine for the treatment of a wide range of infections in domestic animals
The absolute and relative weights of spleen were significantly (P < 0.05) increased in male rats when tylosin was administered at doses of 10 and 200 mg/kg b.w., whereas the spleen weight was unchanged in female rats (Table 1)
Tylosin did not show any significant effect on the body weight and organ weight except the thymus and spleen, which differed between male and female rats
Summary
Tylosin is one of the most commonly used macrolide antibiotics in veterinary medicine for the treatment of a wide range of infections in domestic animals. This agent is active against most Gram-positive bacteria, mycoplasma and certain Gram-negative bacteria. Few studies have already shown diverse side effects when tylosin is administered to animals. It has been reported that tylosin has an effect on increasing the antibody production and can modulate the number of antibody producing cells in chickens (Baba et al 1998b). The aim of this study was to evaluate the physiological effects of tylosin in vivo in rats
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