Physiological Functions of RNA-Binding Motif Protein 3

Abstract

RNA-binding motif protein 3 (RBM3) is a cold stress-induced glycine-rich RNA-binding protein that plays a crucial role in regulating global protein synthesis and is involved in cold stress-induced responses, neuroprotection, cytoprotection, antiapoptotic processes, and cell proliferation. RBM3 plays an essential role in tumor progression and metastasis. In this review, we explored the structure, dynamic distribution, neuroprotective functions under mild hypothermia, and cytoprotective functions under adverse stress conditions of RBM3, as well as its regulatory role in tumor progression and metastasis based on findings from recent related research.