Abstract
Recent developments in the field of lung mechanics relating to the problem of obstructive airway disease and its detection are reviewed. The importance of studying the behavior of the intrapulmonary airways during the compressed as well as the noncompressed state is stressed. The role of premature “airway closure,” in contributing to the abnormalities of gas exchange associated with disease in the small peripheral airways is discussed. The possibility is explored that some alternative methods for detecting small airway disease other than frequency dependence of dynamic compliance may be developed. Some physiological approaches to studying the behavior of small peripheral airways in human subjects during life are presented.
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