Abstract
The pharmacological and electrophysiological characteristics of the oviduct of the preovulatory baboon (Papio anubis) have been investigated. The longitudinal and circular muscle of both isthmus and ampulla contract upon transmural stimulation, and this effect is completely blocked by phentolamine, guanethidine, and tetrodotoxin, suggesting that contractions are mediated by norepinephrine released from adrenergic nerves acting on α-receptors on the smooth muscle. In circular preparations of the isthmus and in ampulla, nonadrenergic, noncholinergic inhibitory nerves could be demonstrated in the presence of guanethidine. Pharmacologically, the oviductal smooth muscle is contracted by norepinephrine, histamine, acetylcholine, Substance P, 5-hydroxytryptamine, ATP, adenosine, PGF2α, U44069, and U46619 and is inhibited by PGE2 and isoproterenol. Extracellular recording of electrical activity of the ampulla determined that electrical impulses traveled at a velocity of 2–5 mm/sec, that there was a reduction in conduction velocity towards ovulation, and that following ovulation the duration of the electrical bursts increased.
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