Physiological and histopathological assessment of the liver and kidney of Rat following administration of a acetaminophen and enrofloxacine

Abstract

The study included three groups of rats, 5rats for each group each group of five rats. The first group (control) given distill water, the second received I.P 0.01ml acetaminophen and 0.01ml enrofloxacin 1\ml, while the third received I.P 0.01ml of acetaminophen and then after half an hour received 0.01 ml of enrofloxacin for 15 days. Haematological analysis of control and treatment group are presented that all groups no significant in haemoglobin concentration, and packed cell volume. While increased white blood cells in group 2 and 3 counts compared to the control. The results of liver enzyme analysis results indicated that group 2 caused a significant alteration in liver enzymes value compared with group1 and 3, while the results of urea and creatnine analysis there were insignificant alterations in urea and creatnine in both groups 2 and 3 comperes with group1. The histopathological examination (group second) of the liver showed that the thickening wall with fibrosis in the periportal area infiltration of inflammatory cells in the necrotic change of the hepatocytes massive vacuolation of the kupffer cell was the present intensity in the sinusoid. Lymphocyte infiltration in the kidney, congestion with glomerulus and tubular damage. In the third group, the histopathological changes were less when compared to the first group. The present study observed when using drugs at the same time leads to harmful effects on the body.