Abstract
The biochemistry and physiology of a number of nuclear and one extranuclear oligomycin-resistant mutants of Aspergillus nidulans have been studied. All the mutants showed at least a 50-fold increase in oligomycin resistance compared with the wild type, and all were cross-resistant to rutamycin. A number of the nuclear mutants also exhibited cross-resistance to venturicidin. None of the mutants were cross-resistant to DCCD, chloramphenicol or cycloheximide. In a total of 6 mutants examined, including the extranuclear mutant, none possessed a mitochondrial ATPase with an in vitro oligomycin resistance greater than about 7 times that of the wild type. The extranuclear mutant, strain OR6, exhibited impaired growth ability on drug-free media. On oligomycin, rutamycin or chloramphenicol, however, its impaired growth ability was not apparent. The extranuclear mutant also possessed an altered cytochrome spectrum.
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