Abstract
Over a century ago Duchenne summarized his life's work in the third edition of his famous book De L'electrisation Localisee (1872), which laid the foundation of electrophysiology of muscle and clinical myology. Primary muscle diseases are ad mittedly uncommon but, for the sufferers and their families, of grave import since for most no effec tive therapy is as yet available. However, skeletal muscle, which amounts to about 40% of the body mass, also reflects disordered function of a wide range of afflictions of body and mind in the common symptoms of weakness and fatigue. This review will indicate developments in techniques for investigating these symptoms and present a new diagnostic approach based on consideration of skeletal muscle as a machine, the prime function of which is to generate force.
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